Rheumatic fever incl heart disease


rheumatic fever: Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Remove individuals based on genotype QC


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Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

Summary Statistics

Key figures

All Female Male
Number of individuals 976 436 540
Unadjusted prevalence (%) 0.26 0.21 0.32
Mean age at first event (years) 50.34 47.60 52.54


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.73 [2.02, 3.68] 5.3e-11 353
15 years 0.01 1.49 [1.15, 1.93] 2.8e-3 133
5 years 0.00 2.49 [1.95, 3.17] 2.4e-13 79
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: I9_RHEUFEV – Rheumatic fever incl heart disease
GWS hits:

Survival analyses between endpoints


before Rheumatic fever incl heart disease
after Rheumatic fever incl heart disease

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Drugs most likely to be purchased after Rheumatic fever incl heart disease

Endpoint not on priority list, no data to show.