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Atrial fibrillation and flutter

DOID EFO MESH SNOMED PheWeb

I9_AF

atrial fibrillation: A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I48
Hospital discharge: ICD-9 4273
Hospital discharge: ICD-8 42792
Cause of death: ICD-10 I48
Cause of death: ICD-9 4273
Cause of death: ICD-8 42792
KELA reimbursements: KELA codes 207|351
KELA reimbursements: ICD-10 I48

3 out of 7 registries used, show all original rules.

47091

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Check minimum number of events None

47091

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Include endpoints

47091

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Remove individuals based on genotype QC

45766

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I9_AF

Control definitions

Control exclude FG_CVD

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I30-I52
Name in latin Fibrillatio atriorum

Summary Statistics

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Key figures

All Female Male
Number of individuals 45766 17109 28657
Unadjusted prevalence (%) 12.14 8.12 17.23
Mean age at first event (years) 67.88 69.75 66.76

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.98 [2.71, 3.29] <1e-100 11278
15 years 0.01 1.60 [1.46, 1.74] 8.4e-26 4162
5 years 0.00 3.46 [3.22, 3.72] <1e-100 3828
1 year 0.00 9.71 [8.84, 10.68] <1e-100 2412

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_AF – Atrial fibrillation and flutter
GWS hits: 102

Survival analyses between endpoints

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Plot

before Atrial fibrillation and flutter
after Atrial fibrillation and flutter

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Atrial fibrillation and flutter

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