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Discontinuity and dislocation of ear ossicles

DOID EFO MESH SNOMED PheWeb

H8_DISCON

Otitis media: Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H74.2
Cause of death: ICD-10 H74.2

2 out of 7 registries used, show all original rules.

134

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Check minimum number of events None

134

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Include endpoints None

134

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Remove individuals based on genotype QC

126

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H8_DISCON

Control definitions

Control exclude H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H74
Name in latin Discontinuitas ossiculorum auditoriorum

Summary Statistics

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Key figures

All Female Male
Number of individuals 126 71 55
Unadjusted prevalence (%) 0.03 0.03 0.03
Mean age at first event (years) 50.26 48.18 52.93

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H8_DISCON – Discontinuity and dislocation of ear ossicles
GWS hits:

Survival analyses between endpoints

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Not a core endpoint, no data to show.

Drugs most likely to be purchased after Discontinuity and dislocation of ear ossicles

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Endpoint not on priority list, no data to show.