≡ Risteys
R9

Documentation Changelog GitHub Contact & Feedback

Cholesteatoma of middle ear

DOID EFO MESH SNOMED PheWeb

H8_CHOLEASTOMA

cholesteatoma of middle ear: A non-neoplastic lesion characterized by the proliferation of keratinizing squamous epithelium in the middle ear that results in the accumulation of keratin and cells. It is usually caused by repeated infections. If left untreated, it may increase in size and destroy the adjacent delicate bones of the middle ear.

Endpoint definition

↥
FinnGen phenotype data

392423 individuals

diagram downward connector

Apply sex-specific rule None

392423

diagram downward connector

Check conditions None

392423

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H71
Hospital discharge: ICD-9 3853
Hospital discharge: ICD-8 38700
Cause of death: ICD-10 H71
Cause of death: ICD-9 3853
Cause of death: ICD-8 38700

2 out of 7 registries used, show all original rules.

1512

diagram downward connector

Check minimum number of events None

1512

diagram downward connector

Include endpoints None

1512

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

1447

diagram downward connector
H8_CHOLEASTOMA

Control definitions

Control exclude H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H65-H75
Name in latin Cholesteatoma auris mediae

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 1447 634 813
Unadjusted prevalence (%) 0.38 0.30 0.49
Mean age at first event (years) 47.94 46.32 49.21

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.10 [0.68, 1.79] 7.0e-1 220
15 years 0.01 0.84 [0.56, 1.24] 3.8e-1 98
5 years 0.00 1.26 [0.85, 1.88] 2.6e-1 39
1 year 0.00 2.31 [1.29, 4.15] 5.0e-3 13

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: H8_CHOLEASTOMA – Cholesteatoma of middle ear
GWS hits:

Survival analyses between endpoints

↥

Plot

before Cholesteatoma of middle ear
after Cholesteatoma of middle ear

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Cholesteatoma of middle ear

↥

Endpoint not on priority list, no data to show.