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Retinopathy of prematurity

DOID EFO MESH SNOMED PheWeb

H7_RETINOPATPREMAT

retinopathy of prematurity: A bilateral retinopathy occurring in premature infants treated with excessively high concentrations of oxygen, characterized by vascular dilatation, proliferation, and tortuosity, edema, and retinal detachment, with ultimate conversion of the retina into a fibrous mass that can be seen as a dense retrolental membrane. Usually growth of the eye is arrested and may result in microophthalmia, and blindness may occur. (Dorland, 27th ed)

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H35.1
Hospital discharge: ICD-9 3622A
Hospital discharge: ICD-8 37704
Cause of death: ICD-10 H35.1
Cause of death: ICD-9 3622A
Cause of death: ICD-8 37704

2 out of 7 registries used, show all original rules.

89

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Check minimum number of events None

89

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Include endpoints None

89

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Remove individuals based on genotype QC

87

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H7_RETINOPATPREMAT

Control definitions

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35
Name in latin Retinopathia praematuritatis

Summary Statistics

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Key figures

All Female Male
Number of individuals 87 54 33
Unadjusted prevalence (%) 0.02 0.03 0.02
Mean age at first event (years) 36.16 39.45 30.76

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_RETINOPATPREMAT – Retinopathy of prematurity
GWS hits:

Survival analyses between endpoints

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Plot

before Retinopathy of prematurity
after Retinopathy of prematurity

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Drugs most likely to be purchased after Retinopathy of prematurity

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Endpoint not on priority list, no data to show.