Background retinopathy and retinal vascular changes

DOID EFO MESH SNOMED PheWeb

H7_BCKRNDRETINOPAT

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H35.0

Hospital discharge: ICD-9 3621|3624A

Hospital discharge: ICD-8 36701|37705|37709|37712

Cause of death: ICD-10 H35.0

Cause of death: ICD-9 3621|3624A

Cause of death: ICD-8 36701|37705|37709|37712

2 out of 7 registries used, show all original rules.

556

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Check minimum number of events None

556

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Include endpoints None

556

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Remove individuals based on genotype QC

533

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H7_BCKRNDRETINOPAT

Control definitions

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF6

Parent code in ICD-10 H35

Name in latin Retinopathia recessualis et commutationes vasculares retinae

NAME	H7_BCKRNDRETINOPAT
CONTROL_EXCLUDE	H7_CHOROIDRETINA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H350
HD_ICD_9	3621\|3624A
HD_ICD_8	36701\|37705\|37709\|37712
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H350
COD_ICD_9	3621\|3624A
COD_ICD_8	36701\|37705\|37709\|37712
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Background retinopathy and retinal vascular changes based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	533	255	278
Unadjusted prevalence (%)	0.14	0.12	0.17
Mean age at first event (years)	55.23	55.78	54.73

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.60 [0.77, 3.33]	2.1e-1	84
15 years	0.01	1.19 [0.59, 2.36]	6.3e-1	42
5 years	0.00	2.25 [1.26, 4.02]	5.9e-3	24
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_BCKRNDRETINOPAT – Background retinopathy and retinal vascular changes
GWS hits: 1

Survival analyses between endpoints

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Plot

before Background retinopathy and retinal vascular changes
after Background retinopathy and retinal vascular changes

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Table

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Drugs most likely to be purchased after Background retinopathy and retinal vascular changes

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Endpoint not on priority list, no data to show.