Background retinopathy and retinal vascular changes

H7_BCKRNDRETINOPAT

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

Endpoint definition

FinnGen phenotype data

392423 individuals

diagram downward connector

Apply sex-specific rule None

392423

diagram downward connector

Check conditions None

392423

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H35.0
Hospital discharge: ICD-9 3621|3624A
Hospital discharge: ICD-8 36701|37705|37709|37712
Cause of death: ICD-10 H35.0
Cause of death: ICD-9 3621|3624A
Cause of death: ICD-8 36701|37705|37709|37712

2 out of 7 registries used, show all original rules.

556

diagram downward connector

Check minimum number of events None

556

diagram downward connector

Include endpoints None

556

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

533

diagram downward connector
H7_BCKRNDRETINOPAT

Control definitions

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF6
Parent code in ICD-10 H35
Name in latin Retinopathia recessualis et commutationes vasculares retinae

Summary Statistics

Key figures

All Female Male
Number of individuals 533 255 278
Unadjusted prevalence (%) 0.14 0.12 0.17
Mean age at first event (years) 55.23 55.78 54.73

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.60 [0.77, 3.33] 2.1e-1 84
15 years 0.01 1.19 [0.59, 2.36] 6.3e-1 42
5 years 0.00 2.25 [1.26, 4.02] 5.9e-3 24
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: H7_BCKRNDRETINOPAT – Background retinopathy and retinal vascular changes
GWS hits: 1

Survival analyses between endpoints

Plot

before Background retinopathy and retinal vascular changes
after Background retinopathy and retinal vascular changes

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Background retinopathy and retinal vascular changes

Endpoint not on priority list, no data to show.