Extrapyramidal and movement disorders

DOID EFO MESH SNOMED PheWeb

G6_XTRAPYR

basal ganglia disease: A disease involving the basal ganglia.

Endpoint definition

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FinnGen phenotype data

392423 individuals

Apply sex-specific rule None

392423

Check conditions None

392423

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G20-G26

Cause of death: ICD-10 G20-G26

2 out of 7 registries used, show all original rules.

9504

Check minimum number of events None

9504

Include endpoints

G6_PARKINSON

G6_PARKSCND

G6_BASDEGENOTH

G6_DYSTON

G6_XTRAPYROTH

10109

Remove individuals based on genotype QC

9833

G6_XTRAPYR

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

NAME	G6_XTRAPYR
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	G6_PARKINSON\|G6_PARKSCND\|G6_BASDEGENOTH\|G6_DYSTON\|G6_XTRAPYROTH
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G2
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G2
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

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List of similar endpoints to Extrapyramidal and movement disorders based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	9833	4936	4897
Unadjusted prevalence (%)	2.61	2.34	2.95
Mean age at first event (years)	60.73	58.23	63.24

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	3.30 [2.55, 4.29]	2.0e-19	1761
15 years	0.01	2.03 [1.69, 2.44]	2.9e-14	859
5 years	0.00	3.11 [2.67, 3.61]	2.8e-49	575
1 year	0.00	4.40 [3.60, 5.36]	1.7e-48	166

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_XTRAPYR – Extrapyramidal and movement disorders
GWS hits: 3

Survival analyses between endpoints

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Plot

before Extrapyramidal and movement disorders
after Extrapyramidal and movement disorders

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Table

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Drugs most likely to be purchased after Extrapyramidal and movement disorders

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Endpoint not on priority list, no data to show.

≡ Risteys

R9

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R7

R6

R5

R4

R3