Extrapyramidal and movement disorders

G6_XTRAPYR

basal ganglia disease: A disease involving the basal ganglia.

Endpoint definition

FinnGen phenotype data

392423 individuals

diagram downward connector

Apply sex-specific rule None

392423

diagram downward connector

Check conditions None

392423

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G20-G26
Cause of death: ICD-10 G20-G26

2 out of 7 registries used, show all original rules.

9504

diagram downward connector

Check minimum number of events None

9504

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

9833

diagram downward connector
G6_XTRAPYR

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

Summary Statistics

Key figures

All Female Male
Number of individuals 9833 4936 4897
Unadjusted prevalence (%) 2.61 2.34 2.95
Mean age at first event (years) 60.73 58.23 63.24

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.30 [2.55, 4.29] 2.0e-19 1761
15 years 0.01 2.03 [1.69, 2.44] 2.9e-14 859
5 years 0.00 3.11 [2.67, 3.61] 2.8e-49 575
1 year 0.00 4.40 [3.60, 5.36] 1.7e-48 166

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_XTRAPYR – Extrapyramidal and movement disorders
GWS hits: 3

Survival analyses between endpoints

Plot

before Extrapyramidal and movement disorders
after Extrapyramidal and movement disorders

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Extrapyramidal and movement disorders

Endpoint not on priority list, no data to show.