Trigeminal neuralgia


trigeminal neuralgia: Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of theface), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G50.0
Hospital discharge: ICD-9 3501
Hospital discharge: ICD-8 35199
Cause of death: ICD-10 G50.0
Cause of death: ICD-9 3501
Cause of death: ICD-8 35199
KELA reimbursements: KELA codes 119

3 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints None


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Remove individuals based on genotype QC


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Control definitions

Control exclude G6_NERPLEX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G50
Name in latin Neuralgia trigeminalis

Summary Statistics

Key figures

All Female Male
Number of individuals 1599 1115 484
Unadjusted prevalence (%) 0.42 0.53 0.29
Mean age at first event (years) 54.42 52.84 58.05


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.84 [2.03, 3.97] 1.1e-9 156
15 years 0.01 1.82 [1.40, 2.38] 9.9e-6 76
5 years 0.00 2.17 [1.46, 3.23] 1.4e-4 31
1 year 0.00 5.60 [3.21, 9.76] 1.3e-9 15

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: G6_TRINEU – Trigeminal neuralgia
GWS hits: 1

Survival analyses between endpoints


before Trigeminal neuralgia
after Trigeminal neuralgia

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Drugs most likely to be purchased after Trigeminal neuralgia

Endpoint not on priority list, no data to show.