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Paraplegia, diplegia of upper limbs

DOID EFO MESH SNOMED PheWeb

G6_PARDIPLE

paraplegia: Complete paralysis of the lower half of the body including both legs, often caused by damage to the spinal cord. [database_cross_reference: NCIT:P378]

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G82.0, G82.1, G82.2, G83.0
Hospital discharge: ICD-8 34401
Cause of death: ICD-10 G82.0, G82.1, G82.2, G83.0
Cause of death: ICD-8 34401

2 out of 7 registries used, show all original rules.

611

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Check minimum number of events None

611

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Include endpoints None

611

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Remove individuals based on genotype QC

594

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G6_PARDIPLE

Control definitions

Control exclude G6_CPETAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 594 265 329
Unadjusted prevalence (%) 0.16 0.13 0.20
Mean age at first event (years) 52.78 47.06 57.39

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.65 [0.74, 3.65] 2.2e-1 129
15 years 0.01 0.88 [0.41, 1.88] 7.4e-1 33
5 years 0.01 4.09 [2.20, 7.59] 8.2e-6 37
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_PARDIPLE – Paraplegia, diplegia of upper limbs
GWS hits:

Survival analyses between endpoints

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Plot

before Paraplegia, diplegia of upper limbs
after Paraplegia, diplegia of upper limbs

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Paraplegia, diplegia of upper limbs

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Endpoint not on priority list, no data to show.