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Myasthenia gravis

DOID EFO MESH SNOMED PheWeb

G6_MYASTHENIA

Myasthenia gravis: Myasthenia gravis (MG) is a rare, clinically heterogeneous, autoimmune disorder of the neuromuscular junction characterized by fatigable weakness of voluntary muscles.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G70.0#
Hospital discharge: ICD-9 3580
Hospital discharge: ICD-8 7330
Cause of death: ICD-10 G70.0#
Cause of death: ICD-9 3580
Cause of death: ICD-8 7330
KELA reimbursements: KELA codes 108

3 out of 7 registries used, show all original rules.

442

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Check minimum number of events None

442

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Include endpoints None

442

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Remove individuals based on genotype QC

426

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G6_MYASTHENIA

Control definitions

Control exclude G6_MYONEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G70

Summary Statistics

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Key figures

All Female Male
Number of individuals 426 229 197
Unadjusted prevalence (%) 0.11 0.11 0.12
Mean age at first event (years) 52.67 47.28 58.93

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.12 [0.44, 2.84] 8.2e-1 46
15 years 0.00 0.74 [0.32, 1.70] 4.7e-1 16
5 years 0.00 2.17 [1.03, 4.58] 4.1e-2 13
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_MYASTHENIA – Myasthenia gravis
GWS hits: 1

Survival analyses between endpoints

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Plot

before Myasthenia gravis
after Myasthenia gravis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Myasthenia gravis

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Endpoint not on priority list, no data to show.