Normal-pressure hydrocephalus

G6_HCNP

normal pressure hydrocephalus: A form of compensated hydrocephalus characterized clinically by a slowly progressive gait disorder (see gait disorders, neurologic), progressive intellectual decline, and urinary incontinence. Spinal fluid pressure tends to be in the high normal range. This condition may result from processes which interfere with the absorption of csf including subarachnoid hemorrhage, chronic meningitis, and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp631-3)

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G91.2
Cause of death: ICD-10 G91.2

2 out of 7 registries used, show all original rules.

787

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Check minimum number of events None

787

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Include endpoints None

787

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Remove individuals based on genotype QC

767

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G6_HCNP

Control definitions

Control exclude G6_HYDROCEPH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G91
Name in latin Hydrocephalia normotensiva

Summary Statistics

Key figures

All Female Male
Number of individuals 767 334 433
Unadjusted prevalence (%) 0.20 0.16 0.26
Mean age at first event (years) 70.63 69.67 71.38

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.62 [2.33, 9.16] 1.2e-5 174
15 years 0.01 2.06 [1.17, 3.62] 1.2e-2 66
5 years 0.01 4.92 [3.47, 7.00] 5.8e-19 73
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_HCNP – Normal-pressure hydrocephalus
GWS hits: 1

Survival analyses between endpoints

Plot

before Normal-pressure hydrocephalus
after Normal-pressure hydrocephalus

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Normal-pressure hydrocephalus

Endpoint not on priority list, no data to show.