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Toxic encephalopathy

DOID EFO MESH SNOMED PheWeb

G6_ENCEPHTOX

toxic encephalopathy: A group of neurologic disorders caused by damage to the nervous system following exposure to pharmacologic, biologic, and chemical agents. Examples of neurotoxins include chemotherapy agents, radiation treatment, heavy metals, pesticides, and food additives.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G92
Hospital discharge: ICD-9 3498B
Hospital discharge: ICD-8 32302
Cause of death: ICD-10 G92
Cause of death: ICD-9 3498B
Cause of death: ICD-8 32302

2 out of 7 registries used, show all original rules.

61

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Check minimum number of events None

61

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Include endpoints None

61

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Remove individuals based on genotype QC

60

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G6_ENCEPHTOX

Control definitions

Control exclude G6_OTHNEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G90-G99
Name in latin Encephalopathia toxica

Summary Statistics

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Key figures

All Female Male
Number of individuals 60 14 46
Unadjusted prevalence (%) 0.02 0.01 0.03
Mean age at first event (years) 54.65 53.22 55.09

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_ENCEPHTOX – Toxic encephalopathy
GWS hits:

Survival analyses between endpoints

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Plot

before Toxic encephalopathy
after Toxic encephalopathy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Toxic encephalopathy

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Endpoint not on priority list, no data to show.