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Other and unspecified degenerative diseases of nervous system

DOID EFO MESH SNOMED PheWeb

G6_DEGENOTH

Lewy body dementia: A progressive form of dementia characterized by the presence of protein deposits called Lewy bodies in the midbrain and cerebral cortex, and loss of cholinergic and dopaminergic neurons. The signs and symptoms overlap with Alzheimer and Parkinson disease.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G31.8, G31.9, G32*
Hospital discharge: ICD-9 331[8-9]
Hospital discharge: ICD-8 32303
Cause of death: ICD-10 G31.8, G31.9, G32*
Cause of death: ICD-9 331[8-9]
Cause of death: ICD-8 32303

2 out of 7 registries used, show all original rules.

563

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Check minimum number of events None

563

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Include endpoints None

563

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Remove individuals based on genotype QC

545

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G6_DEGENOTH

Control definitions

Control exclude G6_NEURODEG

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 545 207 338
Unadjusted prevalence (%) 0.14 0.10 0.20
Mean age at first event (years) 66.66 63.07 68.86

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_DEGENOTH – Other and unspecified degenerative diseases of nervous system
GWS hits: 3

Survival analyses between endpoints

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Plot

before Other and unspecified degenerative diseases of nervous system
after Other and unspecified degenerative diseases of nervous system

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other and unspecified degenerative diseases of nervous system

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