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Depression

DOID EFO MESH PheWeb

F5_DEPRESSIO

unipolar depression: A mood disorder having a clinical course involving one or more episodes of serious psychological depression that last two or more weeks each, do not have intervening episodes of mania or hypomania, and are characterized by a loss of interest or pleasure in almost all activities and by some or all of disturbances of appetite, sleep, or psychomotor functioning, a decrease in energy, difficulties in thinking or making decisions, loss of self-esteem or feelings of guilt, and suicidal thoughts or attempts.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F32, F33
Hospital discharge: ICD-9 2961|2968|3004
Cause of death: ICD-10 F32, F33
Cause of death: ICD-9 2961|2968|3004

2 out of 7 registries used, show all original rules.

45030

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Check minimum number of events None

45030

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Include endpoints

45064

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Remove individuals based on genotype QC

43280

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F5_DEPRESSIO

Control definitions

Control exclude F5_MOOD

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Summary Statistics

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Key figures

All Female Male
Number of individuals 43280 29150 14130
Unadjusted prevalence (%) 11.48 13.83 8.50
Mean age at first event (years) 41.87 40.34 45.04

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.86 [2.48, 3.30] 1.5e-47 2868
15 years 0.01 1.91 [1.69, 2.16] 2.7e-25 1245
5 years 0.00 3.37 [3.02, 3.77] <1e-100 693
1 year 0.00 8.81 [7.62, 10.18] <1e-100 355

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_DEPRESSIO – Depression
GWS hits: 18

Survival analyses between endpoints

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Plot

before Depression
after Depression

loading spinner Loading survival analyses plot