Alcohol dependence

DOID EFO MESH SNOMED PheWeb

F5_ALCOHOL_DEPENDENCE

alcohol dependence: Physical and psychological dependence on alcohol.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F10.2

Hospital discharge: ICD-9 303

Hospital discharge: ICD-8 303

Cause of death: ICD-10 F10.2

Cause of death: ICD-9 303

Cause of death: ICD-8 303

2 out of 7 registries used, show all original rules.

10157

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Check minimum number of events None

10157

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Include endpoints None

10157

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Remove individuals based on genotype QC

9876

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F5_ALCOHOL_DEPENDENCE

Control definitions

Control exclude F5_SUBSTANCE

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF3

Parent code in ICD-10 F10

NAME	F5_ALCOHOL_DEPENDENCE
CONTROL_EXCLUDE	F5_SUBSTANCE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	F102
HD_ICD_9	303
HD_ICD_8	303
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	F102
COD_ICD_9	303
COD_ICD_8	303
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Alcohol dependence based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	9876	2691	7185
Unadjusted prevalence (%)	2.62	1.28	4.32
Mean age at first event (years)	43.50	41.21	44.36

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	4.34 [3.50, 5.37]	5.9e-41	2208
15 years	0.02	2.85 [2.44, 3.33]	2.6e-40	922
5 years	0.00	4.47 [3.92, 5.09]	<1e-100	460
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_ALCOHOL_DEPENDENCE – Alcohol dependence
GWS hits: 3

Survival analyses between endpoints

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Plot

before Alcohol dependence
after Alcohol dependence

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Table

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Drugs most likely to be purchased after Alcohol dependence

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Endpoint not on priority list, no data to show.