Secondary lactase deficiency

E4_LACTOSEC

lactose intolerance: Inability to fully digest and absorb lactose due to limited or no lactase activity in the small intestine. Congenital intolerance is inherited following an autosomal recessive pattern but is rare. It is more often due to a gradual decline of lactase production in adulthood following the ingestion of fewer lactose-containing foods or secondary to an intestinal mucosal brush-border injury. Prevalence is highest among Asians, Native Americans and Africans. Clinical signs include abdominal cramping, bloating, flatulence and diarrhea following the dietary intake of lactose.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E73.1
Cause of death: ICD-10 E73.1

2 out of 7 registries used, show all original rules.

38

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Check minimum number of events None

38

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Include endpoints None

38

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Remove individuals based on genotype QC

36

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E4_LACTOSEC

Control definitions

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E73
Name in latin Deficientia lactasae secundaria

Summary Statistics

Key figures

All Female Male
Number of individuals 36 23 13
Unadjusted prevalence (%) 0.01 0.01 0.01
Mean age at first event (years) 42.40 38.74 48.86

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_LACTOSEC – Secondary lactase deficiency
GWS hits:

Survival analyses between endpoints

Not a core endpoint, no data to show.

Drugs most likely to be purchased after Secondary lactase deficiency

Endpoint not on priority list, no data to show.