Lactose intolerance, other/unspecified


lactose intolerance: Inability to fully digest and absorb lactose due to limited or no lactase activity in the small intestine. Congenital intolerance is inherited following an autosomal recessive pattern but is rare. It is more often due to a gradual decline of lactase production in adulthood following the ingestion of fewer lactose-containing foods or secondary to an intestinal mucosal brush-border injury. Prevalence is highest among Asians, Native Americans and Africans. Clinical signs include abdominal cramping, bloating, flatulence and diarrhea following the dietary intake of lactose.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E73.8, E73.9
Hospital discharge: ICD-9 2713A
Cause of death: ICD-10 E73.8, E73.9
Cause of death: ICD-9 2713A

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints None


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Remove individuals based on genotype QC


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Control definitions

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 691 467 224
Unadjusted prevalence (%) 0.18 0.22 0.13
Mean age at first event (years) 38.84 38.04 40.51


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.00 [1.54, 5.84] 1.2e-3 68
15 years 0.01 2.04 [1.16, 3.59] 1.3e-2 37
5 years 0.00 2.05 [1.15, 3.64] 1.5e-2 13
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_LACTONAS – Lactose intolerance, other/unspecified
GWS hits: 1

Survival analyses between endpoints


before Lactose intolerance, other/unspecified
after Lactose intolerance, other/unspecified

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Drugs most likely to be purchased after Lactose intolerance, other/unspecified

Endpoint not on priority list, no data to show.