Disorders of iron metabolism

E4_IRON_MET

hereditary hemochromatosis type 1: Hemochromatosis type 1 (classic) is the most common form of hereditary hemochromatosis (HH), a group of diseases characterized by excessive tissue iron deposition. Due to its incidence (1/200-1/1000), it is not considered as a rare disease, unlike the other subforms of the disease

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E83.1
Hospital discharge: ICD-9 2750
Cause of death: ICD-10 E83.1
Cause of death: ICD-9 2750

2 out of 7 registries used, show all original rules.

339

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Check minimum number of events None

339

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Include endpoints None

339

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Remove individuals based on genotype QC

324

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E4_IRON_MET

Control definitions

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E83
Name in latin Perturbationes metabolismi ferri

Summary Statistics

Key figures

All Female Male
Number of individuals 324 147 177
Unadjusted prevalence (%) 0.09 0.07 0.11
Mean age at first event (years) 55.68 56.34 55.12

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_IRON_MET – Disorders of iron metabolism
GWS hits: 2

Survival analyses between endpoints

Plot

before Disorders of iron metabolism
after Disorders of iron metabolism

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Drugs most likely to be purchased after Disorders of iron metabolism

Endpoint not on priority list, no data to show.