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Hypopituitarism

DOID EFO MESH SNOMED PheWeb

E4_HYPOPIT

hypopituitarism: A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E23.00, E23.01, E23.02, E23.03, E23.04, E23.05, E23.06, E23.08, E23.09
Hospital discharge: ICD-9 2532
Hospital discharge: ICD-8 2531
Cause of death: ICD-10 E23.00, E23.01, E23.02, E23.03, E23.04, E23.05, E23.06, E23.08, E23.09
Cause of death: ICD-9 2532
Cause of death: ICD-8 2531
KELA reimbursements: KELA codes 101

3 out of 7 registries used, show all original rules.

1975

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Check minimum number of events None

1975

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Include endpoints None

1975

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Remove individuals based on genotype QC

1902

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E4_HYPOPIT

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 1902 698 1204
Unadjusted prevalence (%) 0.50 0.33 0.72
Mean age at first event (years) 43.72 40.90 45.35

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.92 [2.71, 5.67] 3.8e-13 116
15 years 0.01 1.73 [1.15, 2.60] 8.8e-3 44
5 years 0.00 3.38 [2.12, 5.39] 3.2e-7 32
1 year 0.00 9.75 [5.25, 18.09] 5.5e-13 19

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYPOPIT – Hypopituitarism
GWS hits:

Survival analyses between endpoints

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Plot

before Hypopituitarism
after Hypopituitarism

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Drugs most likely to be purchased after Hypopituitarism

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Endpoint not on priority list, no data to show.