Hyperaldosteronism

E4_HYPERALDO

hyperaldosteronism: Overproduction of aldosterone by the adrenal glands, which may lead to hypokalemia and/or hypernatremia. [ NCIT:P378 ]

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E26
Hospital discharge: ICD-9 2551
Hospital discharge: ICD-8 25500
Cause of death: ICD-10 E26
Cause of death: ICD-9 2551
Cause of death: ICD-8 25500

2 out of 7 registries used, show all original rules.

717

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Check minimum number of events None

717

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Include endpoints None

717

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Remove individuals based on genotype QC

690

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E4_HYPERALDO

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E20-E35
Name in latin Hyperaldosteronismus

Summary Statistics

Key figures

All Female Male
Number of individuals 690 383 307
Unadjusted prevalence (%) 0.18 0.18 0.18
Mean age at first event (years) 56.36 54.06 59.23

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.50 [1.25, 4.99] 9.6e-3 51
15 years 0.01 1.62 [0.80, 3.31] 1.8e-1 26
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_HYPERALDO – Hyperaldosteronism
GWS hits: 2

Survival analyses between endpoints

Plot

before Hyperaldosteronism
after Hyperaldosteronism

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hyperaldosteronism

Endpoint not on priority list, no data to show.