Unspecified diabetes with ophthalmic complications

E4_DMNASOPTH

diabetic retinopathy: A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E12.3+, E13.3+, E14.3+
Hospital discharge: ICD-9 2504C|2503X
Cause of death: ICD-10 E12.3+, E13.3+, E14.3+
Cause of death: ICD-9 2504C|2503X

2 out of 7 registries used, show all original rules.

91

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Check minimum number of events None

91

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Include endpoints None

91

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Remove individuals based on genotype QC

88

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E4_DMNASOPTH

Control definitions

Control exclude E4_DIABETES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 88 32 56
Unadjusted prevalence (%) 0.02 0.02 0.03
Mean age at first event (years) 55.01 50.97 57.32

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_DMNASOPTH – Unspecified diabetes with ophthalmic complications
GWS hits: 4

Survival analyses between endpoints

Not a core endpoint, no data to show.

Drugs most likely to be purchased after Unspecified diabetes with ophthalmic complications

Endpoint not on priority list, no data to show.