Cushing syndrome

DOID EFO MESH SNOMED PheWeb

E4_CUSHING

hyperaldosteronism: Overproduction of aldosterone by the adrenal glands, which may lead to hypokalemia and/or hypernatremia. [ NCIT:P378 ]

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E24

Hospital discharge: ICD-9 2550|2593

Hospital discharge: ICD-8 2580

Cause of death: ICD-10 E24

Cause of death: ICD-9 2550|2593

Cause of death: ICD-8 2580

2 out of 7 registries used, show all original rules.

303

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Check minimum number of events None

303

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Include endpoints None

303

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Remove individuals based on genotype QC

293

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E4_CUSHING

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF6

Parent code in ICD-10 E20-E35

Name in latin Syndroma Cushing

NAME	E4_CUSHING
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E24
HD_ICD_9	2550\|2593
HD_ICD_8	2580
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E24
COD_ICD_9	2550\|2593
COD_ICD_8	2580
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Cushing syndrome based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	293	206	87
Unadjusted prevalence (%)	0.08	0.10	0.05
Mean age at first event (years)	46.82	44.93	51.31

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_CUSHING – Cushing syndrome
GWS hits: 1

Survival analyses between endpoints

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Plot

before Cushing syndrome
after Cushing syndrome

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Table

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Drugs most likely to be purchased after Cushing syndrome

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Endpoint not on priority list, no data to show.