Cushing syndrome


hyperaldosteronism: Overproduction of aldosterone by the adrenal glands, which may lead to hypokalemia and/or hypernatremia. [ NCIT:P378 ]

Endpoint definition

FinnGen phenotype data

392423 individuals

diagram downward connector

Apply sex-specific rule None


diagram downward connector

Check conditions None


diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E24
Hospital discharge: ICD-9 2550|2593
Hospital discharge: ICD-8 2580
Cause of death: ICD-10 E24
Cause of death: ICD-9 2550|2593
Cause of death: ICD-8 2580

2 out of 7 registries used, show all original rules.


diagram downward connector

Check minimum number of events None


diagram downward connector

Include endpoints None


diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC


diagram downward connector

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF6
Parent code in ICD-10 E20-E35
Name in latin Syndroma Cushing

Summary Statistics

Key figures

All Female Male
Number of individuals 293 206 87
Unadjusted prevalence (%) 0.08 0.10 0.05
Mean age at first event (years) 46.82 44.93 51.31


Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_CUSHING – Cushing syndrome
GWS hits: 1

Survival analyses between endpoints


before Cushing syndrome
after Cushing syndrome

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Cushing syndrome

Endpoint not on priority list, no data to show.