Acidosis

DOID EFO MESH SNOMED PheWeb

E4_ACIDOSIS

lactic acidosis: Metabolic disease characterized by the accumulation of lactate in the body. It is caused by tissue hypoxia

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E87.2

Hospital discharge: ICD-9 2762

Hospital discharge: ICD-8 78869

Cause of death: ICD-10 E87.2

Cause of death: ICD-9 2762

Cause of death: ICD-8 78869

2 out of 7 registries used, show all original rules.

494

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Check minimum number of events None

494

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Include endpoints None

494

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Remove individuals based on genotype QC

479

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E4_ACIDOSIS

Control definitions

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E87

Name in latin Acidosis

NAME	E4_ACIDOSIS
CONTROL_EXCLUDE	E4_METABOLIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E872
HD_ICD_9	2762
HD_ICD_8	78869
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E872
COD_ICD_9	2762
COD_ICD_8	78869
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Or the full data table

Similar endpoints

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List of similar endpoints to Acidosis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	479	181	298
Unadjusted prevalence (%)	0.13	0.09	0.18
Mean age at first event (years)	63.10	60.40	64.74

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_ACIDOSIS – Acidosis
GWS hits: 1

Survival analyses between endpoints

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Plot

before Acidosis
after Acidosis

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Table

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Drugs most likely to be purchased after Acidosis

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Endpoint not on priority list, no data to show.