Sickle-cell disorders

D3_SICKLECELLDIS

obsolete_sickle cell disease: ['A blood disorder characterized by the appearance of sickle-shaped red blood cells and anemia.']

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D57
Hospital discharge: ICD-9 282[5-6]
Cause of death: ICD-10 D57
Cause of death: ICD-9 282[5-6]

2 out of 7 registries used, show all original rules.

67

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Check minimum number of events None

67

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Include endpoints None

67

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Remove individuals based on genotype QC

54

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D3_SICKLECELLDIS

Control definitions

Control exclude D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D55-D59
Name in latin Morbi meniscocytici

Summary Statistics

Key figures

All Female Male
Number of individuals 54 26 28
Unadjusted prevalence (%) 0.01 0.01 0.02
Mean age at first event (years) 59.16 58.31 59.95

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: D3_SICKLECELLDIS – Sickle-cell disorders
GWS hits:

Survival analyses between endpoints

Plot

before Sickle-cell disorders
after Sickle-cell disorders

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Sickle-cell disorders

Endpoint not on priority list, no data to show.