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Other disorders of white blood cells

DOID EFO MESH SNOMED PheWeb

D3_OTHERWHITECELL

Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D72
Cause of death: ICD-10 D72

2 out of 7 registries used, show all original rules.

1467

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Check minimum number of events None

1467

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Include endpoints

1555

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Remove individuals based on genotype QC

1483

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D3_OTHERWHITECELL

Control definitions

Control exclude D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D70-D77
Name in latin Aliae morbositates leucocytorum

Similar endpoints

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List of similar endpoints to Other disorders of white blood cells based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 1483 785 698
Unadjusted prevalence (%) 0.39 0.37 0.42
Mean age at first event (years) 54.76 50.84 59.17

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 6.09 [4.28, 8.65] 8.8e-24 210
15 years 0.02 2.88 [2.11, 3.93] 2.6e-11 77
5 years 0.01 6.68 [4.75, 9.40] 1.1e-27 73
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_OTHERWHITECELL – Other disorders of white blood cells
GWS hits:

Survival analyses between endpoints

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Plot

before Other disorders of white blood cells
after Other disorders of white blood cells

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Drugs most likely to be purchased after Other disorders of white blood cells

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Endpoint not on priority list, no data to show.