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Hypersplenism

DOID EFO MESH SNOMED PheWeb

D3_HYPERSPLENISM

hypersplenism: Overactive functioning of the spleen, resulting in excessive destruction of blood cells.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D73.1
Hospital discharge: ICD-9 2894
Cause of death: ICD-10 D73.1
Cause of death: ICD-9 2894

2 out of 7 registries used, show all original rules.

108

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Check minimum number of events None

108

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Include endpoints None

108

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Remove individuals based on genotype QC

105

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D3_HYPERSPLENISM

Control definitions

Control exclude D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D73
Name in latin Hypersplenismus

Summary Statistics

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Key figures

All Female Male
Number of individuals 105 47 58
Unadjusted prevalence (%) 0.03 0.02 0.03
Mean age at first event (years) 55.92 53.64 57.77

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_HYPERSPLENISM – Hypersplenism
GWS hits:

Survival analyses between endpoints

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Plot

before Hypersplenism
after Hypersplenism

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hypersplenism

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Endpoint not on priority list, no data to show.