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Other coagulation defects

DOID EFO MESH SNOMED PheWeb

D3_COAGOTHER

thrombophilia: A condition characterized by an abnormally high level of thrombi. Causes include thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, bone marrow disorders, and antiphospholipid antibody syndrome.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D68
Cause of death: ICD-10 D68

2 out of 7 registries used, show all original rules.

1941

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Check minimum number of events None

1941

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Include endpoints

1977

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Remove individuals based on genotype QC

1904

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D3_COAGOTHER

Control definitions

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D65-D69
Name in latin Aliae defectus coagulationis

Similar endpoints

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List of similar endpoints to Other coagulation defects based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 1904 1292 612
Unadjusted prevalence (%) 0.50 0.61 0.37
Mean age at first event (years) 48.69 44.37 57.79

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.20 14.79 [8.52, 25.67] 1.0e-21 266
15 years 0.02 3.21 [2.07, 4.95] 1.6e-7 43
5 years 0.01 6.89 [4.66, 10.19] 4.5e-22 37
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_COAGOTHER – Other coagulation defects
GWS hits: 16

Survival analyses between endpoints

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Plot

before Other coagulation defects
after Other coagulation defects

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Drugs most likely to be purchased after Other coagulation defects

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Endpoint not on priority list, no data to show.