Drug-induced autoimmune haemolytic anaemia

DOID EFO MESH SNOMED PheWeb

D3_AIHA_DRUG

hemolytic anemia: Hemolytic anemia that is not mediated by immune mechanisms.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D59.0#

Hospital discharge: ICD-9 2830B

Hospital discharge: ICD-8 28391

Cause of death: ICD-10 D59.0#

Cause of death: ICD-9 2830B

Cause of death: ICD-8 28391

2 out of 7 registries used, show all original rules.

39

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Check minimum number of events None

39

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Include endpoints None

39

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Remove individuals based on genotype QC

38

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D3_AIHA_DRUG

Control definitions

Control exclude D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D59

Name in latin Anaemia autoimmunis haemolytica medicamentis provocata

NAME	D3_AIHA_DRUG
CONTROL_EXCLUDE	D3_HAEMOLYTICANAEMIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D590
HD_ICD_9	2830B
HD_ICD_8	28391
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D590
COD_ICD_9	2830B
COD_ICD_8	28391
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Drug-induced autoimmune haemolytic anaemia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	38	22	16
Unadjusted prevalence (%)	0.01	0.01	0.01
Mean age at first event (years)	48.81	47.92	50.03

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_AIHA_DRUG – Drug-induced autoimmune haemolytic anaemia
GWS hits:

Survival analyses between endpoints

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Plot

before Drug-induced autoimmune haemolytic anaemia
after Drug-induced autoimmune haemolytic anaemia

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Table

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Drugs most likely to be purchased after Drug-induced autoimmune haemolytic anaemia

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Endpoint not on priority list, no data to show.