Agranulocytosis

DOID MESH PheWeb

D3_AGRANULOCYTOSIS

No definition available.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D70

Hospital discharge: ICD-9 2880

Hospital discharge: ICD-8 2889

Cause of death: ICD-10 D70

Cause of death: ICD-9 2880

Cause of death: ICD-8 2889

2 out of 7 registries used, show all original rules.

3344

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Check minimum number of events None

3344

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Include endpoints None

3344

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Remove individuals based on genotype QC

3234

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D3_AGRANULOCYTOSIS

Control definitions

Control exclude D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D70-D77

Name in latin Agranulocytosis

NAME	D3_AGRANULOCYTOSIS
CONTROL_EXCLUDE	D3_BLOODOTHER
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D70
HD_ICD_9	2880
HD_ICD_8	2889
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D70
COD_ICD_9	2880
COD_ICD_8	2889
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Agranulocytosis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Drug-induced neutropenia

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3234	2063	1171
Unadjusted prevalence (%)	0.86	0.98	0.70
Mean age at first event (years)	56.79	54.84	60.25

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.21	16.02 [9.19, 27.91]	1.2e-22	609
15 years	0.02	2.71 [1.78, 4.12]	3.4e-6	78
5 years	0.01	13.31 [9.21, 19.24]	3.9e-43	210
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_AGRANULOCYTOSIS – Agranulocytosis
GWS hits:

Survival analyses between endpoints

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Plot

before Agranulocytosis
after Agranulocytosis

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Table

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Drugs most likely to be purchased after Agranulocytosis

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Endpoint not on priority list, no data to show.