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Congenital malformations of heart and great arteries

DOID MESH PheWeb

CONGEN_HEART_ARTER

No definition available.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 Q20, Q21, Q22, Q23, Q24, Q25
Hospital discharge: ICD-9 745|746|747[0-3]
Hospital discharge: ICD-8 746|747[0-3]
Cause of death: ICD-10 Q20, Q21, Q22, Q23, Q24, Q25
Cause of death: ICD-9 745|746|747[0-3]
Cause of death: ICD-8 746|747[0-3]

2 out of 7 registries used, show all original rules.

4025

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Check minimum number of events None

4025

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Include endpoints None

4025

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Remove individuals based on genotype QC

3843

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CONGEN_HEART_ARTER

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Congenital malformations of heart and great arteries based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 3843 1993 1850
Unadjusted prevalence (%) 1.02 0.95 1.11
Mean age at first event (years) 31.76 28.94 34.81

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.38 [2.19, 5.23] 3.9e-8 201
15 years 0.01 2.13 [1.43, 3.16] 1.8e-4 88
5 years 0.00 2.98 [1.98, 4.47] 1.5e-7 38
1 year 0.00 9.45 [5.82, 15.36] 1.1e-19 23

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CONGEN_HEART_ARTER – Congenital malformations of heart and great arteries
GWS hits: 4

Survival analyses between endpoints

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Plot

before Congenital malformations of heart and great arteries
after Congenital malformations of heart and great arteries

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Congenital malformations of heart and great arteries

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Endpoint not on priority list, no data to show.