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severe traumatic brain injury, does not include concussion

MESH PheWeb

TRAUMBRAIN_NONCONCUS

No definition available.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 S06.2, S06.3, S06.4, S06.5, S06.6, S06.7
Hospital discharge: ICD-9 85[1-2]
Hospital discharge: ICD-8 85[1-2]
Cause of death: ICD-10 S06.2, S06.3, S06.4, S06.5, S06.6, S06.7
Cause of death: ICD-9 85[1-2]
Cause of death: ICD-8 85[1-2]

2 out of 7 registries used, show all original rules.

6901

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Check minimum number of events None

6901

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Include endpoints None

6901

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Remove individuals based on genotype QC

6687

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TRAUMBRAIN_NONCONCUS

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to severe traumatic brain injury, does not include concussion based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 6687 2243 4444
Unadjusted prevalence (%) 1.77 1.06 2.67
Mean age at first event (years) 59.57 57.70 60.51

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.88 [2.59, 5.83] 6.0e-11 1694
15 years 0.01 1.46 [0.96, 2.23] 7.9e-2 491
5 years 0.00 3.50 [2.72, 4.51] 3.6e-22 432
1 year 0.00 22.92 [18.71, 28.07] <1e-100 653

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: TRAUMBRAIN_NONCONCUS – severe traumatic brain injury, does not include concussion
GWS hits: 1

Survival analyses between endpoints

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Plot

before severe traumatic brain injury, does not include concussion
after severe traumatic brain injury, does not include concussion

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after severe traumatic brain injury, does not include concussion

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Endpoint not on priority list, no data to show.