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Essential (haemorrhagic) thrombocythaemia

DOID EFO MESH PheWeb

THROMBOCYTAEMIA

primary myelofibrosis: Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D47.3
Hospital discharge: ICD-9 2387B
Hospital discharge: ICD-8 2872
Cause of death: ICD-10 D47.3
Cause of death: ICD-9 2387B
Cause of death: ICD-8 2872
Cancer registry: Topography ICD-O-3 ANY
Cancer registry: Morphology ICD-O-3 9962
Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

993

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Check minimum number of events None

993

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Include endpoints None

993

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Remove individuals based on genotype QC

967

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THROMBOCYTAEMIA

Control definitions

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze DF8

Summary Statistics

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Key figures

All Female Male
Number of individuals 967 579 388
Unadjusted prevalence (%) 0.26 0.27 0.23
Mean age at first event (years) 61.07 59.74 63.04

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 5.91 [3.57, 9.79] 5.4e-12 136
15 years 0.02 3.43 [2.17, 5.41] 1.3e-7 73
5 years 0.01 4.35 [3.00, 6.32] 8.8e-15 43
1 year 0.00 6.50 [3.64, 11.60] 2.5e-10 14

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: THROMBOCYTAEMIA – Essential (haemorrhagic) thrombocythaemia
GWS hits: 8

Survival analyses between endpoints

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Plot

before Essential (haemorrhagic) thrombocythaemia
after Essential (haemorrhagic) thrombocythaemia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Essential (haemorrhagic) thrombocythaemia

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Endpoint not on priority list, no data to show.