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Second line medication for Crohn's disease

PheWeb

RX_CROHN_2NDLINE

No definition available.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Medicine purchases: ATC L04AX|L01BB02

1 out of 7 registries used, show all original rules.

20984

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Check minimum number of events

Min. number of events 3

20984

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Include endpoints None

20984

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Remove individuals based on genotype QC

20353

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RX_CROHN_2NDLINE

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF5

Summary Statistics

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Key figures

All Female Male
Number of individuals 20353 12587 7766
Unadjusted prevalence (%) 5.40 5.97 4.67
Mean age at first event (years) 50.56 49.48 52.29

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.16 [1.71, 2.73] 8.2e-11 1201
15 years 0.01 1.41 [1.13, 1.75] 2.2e-3 633
5 years 0.00 2.78 [2.31, 3.35] 4.4e-27 377
1 year 0.00 3.07 [2.33, 4.04] 1.8e-15 75

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: RX_CROHN_2NDLINE – Second line medication for Crohn's disease
GWS hits: 29

Survival analyses between endpoints

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Plot

before Second line medication for Crohn's disease
after Second line medication for Crohn's disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Second line medication for Crohn's disease

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Endpoint not on priority list, no data to show.