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This is a non-core endpoint: only basic statistics are computed.

Fasciculation

R18_FASCICULATION

persistent fetal circulation syndrome: A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 R25.3
Cause of death: ICD-10 R25.3

2 out of 7 registries used, show all original rules.

291

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Check minimum number of events None

291

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Include endpoints None

291

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Remove individuals based on genotype QC

283

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R18_FASCICULATION

Control definitions

Control exclude CD2_BENIGN_FEMALE_GEN_OTH

Extra metadata

Level in the ICD hierarchy 4
Special FASCICULATION
First used in FinnGen datafreeze DF4
Parent code in ICD-10 R25
Name in latin Fasciculationes

Summary Statistics

Key figures

All Female Male
Number of individuals 283 160 123
Unadjusted prevalence (%) 0.08 0.08 0.07
Mean age at first event (years) 49.18 45.03 54.59

Mortality

Not a core endpoint, no data to show.

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Not a core endpoint, no data to show.

Correlations

Index endpoint: R18_FASCICULATION – Fasciculation
GWS hits:

Survival analyses between endpoints

Not a core endpoint, no data to show.

Drugs most likely to be purchased after Fasciculation

Endpoint not on priority list, no data to show.