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Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly

PheWeb

Q17_VACTREL

No definition available.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 Q8726|Q76|Q675|Q42|Q43[5-9]|Q20|Q21|Q22|Q23|Q24|Q25|Q26[1-4]|Q39|Q6[0-4]|Q69[0-1]|Q70[014]|Q71
Hospital discharge: excluded ICD-10 Q20.6, Q21.4, Q25.0, Q25.42, Q39.4, Q39.50, Q39.58, Q39.6
Cause of death: ICD-10 Q8726|Q76|Q675|Q42|Q43[5-9]|Q20|Q21|Q22|Q23|Q24|Q25|Q26[1-4]|Q39|Q6[0-4]|Q69[0-1]|Q70[014]|Q71

2 out of 7 registries used, show all original rules.

5236

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Check minimum number of events None

5236

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Include endpoints None

5236

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Remove individuals based on genotype QC

4984

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Q17_VACTREL

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF6v3

Similar endpoints

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List of similar endpoints to Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 4984 2633 2351
Unadjusted prevalence (%) 1.32 1.25 1.41
Mean age at first event (years) 38.94 36.79 41.34

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.51 [1.34, 4.67] 3.8e-3 299
15 years 0.01 1.65 [0.87, 3.14] 1.3e-1 131
5 years 0.00 3.24 [1.99, 5.25] 2.0e-6 72
1 year 0.00 10.42 [6.39, 17.00] 6.3e-21 43

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: Q17_VACTREL – Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
GWS hits: 4

Survival analyses between endpoints

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Plot

before Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
after Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly

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Endpoint not on priority list, no data to show.