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Polycythaemia vera

DOID EFO MESH SNOMED PheWeb

POLYCYTVERA

chronic myeloproliferative disorder: A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D45
Hospital discharge: ICD-9 2384
Hospital discharge: ICD-8 208
Cause of death: ICD-10 D45
Cause of death: ICD-9 2384
Cause of death: ICD-8 208
Cancer registry: Topography ICD-O-3 ANY
Cancer registry: Morphology ICD-O-3 9950
Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

966

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Check minimum number of events None

966

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Include endpoints None

966

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Remove individuals based on genotype QC

942

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POLYCYTVERA

Control definitions

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze DF8

Summary Statistics

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Key figures

All Female Male
Number of individuals 942 455 487
Unadjusted prevalence (%) 0.25 0.22 0.29
Mean age at first event (years) 63.10 63.07 63.13

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.91 [1.52, 5.54] 1.2e-3 204
15 years 0.01 1.86 [1.18, 2.91] 7.3e-3 102
5 years 0.00 2.76 [1.80, 4.24] 3.0e-6 57
1 year 0.00 5.77 [3.40, 9.80] 8.1e-11 24

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: POLYCYTVERA – Polycythaemia vera
GWS hits: 9

Survival analyses between endpoints

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Plot

before Polycythaemia vera
after Polycythaemia vera

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Polycythaemia vera

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Endpoint not on priority list, no data to show.