Spontaneous abortion

DOID EFO MESH SNOMED PheWeb

O15_ABORT_SPONTAN

habitual abortion: Three or more consecutive spontaneous abortions.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule

Sex only females

219462

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Check conditions None

219462

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 O03

Hospital discharge: ICD-9 634

Hospital discharge: ICD-8 643

Cause of death: ICD-10 O03

Cause of death: ICD-9 634

Cause of death: ICD-8 643

2 out of 7 registries used, show all original rules.

17566

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Check minimum number of events None

17566

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Include endpoints None

17566

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Remove individuals based on genotype QC

16906

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O15_ABORT_SPONTAN

Control definitions

Control exclude O15_PREG_ABORT

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF5

Parent code in ICD-10 O00-O08

Name in latin Abortus spontaneus

NAME	O15_ABORT_SPONTAN
CONTROL_EXCLUDE	O15_PREG_ABORT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	O03
HD_ICD_9	634
HD_ICD_8	643
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	O03
COD_ICD_9	634
COD_ICD_8	643
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Spontaneous abortion based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	16906	16906	-
Unadjusted prevalence (%)	4.48	8.02	-
Mean age at first event (years)	30.44	30.44	-

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	0.57 [0.44, 0.72]	5.9e-6	316
15 years	0.00	0.38 [0.29, 0.51]	1.4e-10	95
5 years	0.00	0.23 [0.12, 0.43]	4.7e-6	11
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: O15_ABORT_SPONTAN – Spontaneous abortion
GWS hits:

Survival analyses between endpoints

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Plot

before Spontaneous abortion
after Spontaneous abortion

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Table

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Drugs most likely to be purchased after Spontaneous abortion

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Endpoint not on priority list, no data to show.