Other and unspecified disorders of skin and subcutaneous tissue

L12_SKINSUBCUTISNAS

skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L98.80, L98.88, L98.9
Hospital discharge: ICD-9 7019X|7098|7099
Hospital discharge: ICD-8 70198|7090[8-9]
Hospital discharge: excluded ICD-9 7098A|7098B
Cause of death: ICD-10 L98.80, L98.88, L98.9
Cause of death: ICD-9 7019X|7098|7099
Cause of death: ICD-8 70198|7090[8-9]
Cause of death: excluded ICD-9 7098A|7098B

2 out of 7 registries used, show all original rules.

2008

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Check minimum number of events None

2008

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Include endpoints None

2008

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Remove individuals based on genotype QC

1950

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L12_SKINSUBCUTISNAS

Control definitions

Control exclude L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 1950 1221 729
Unadjusted prevalence (%) 0.52 0.58 0.44
Mean age at first event (years) 52.31 49.94 56.28

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.73 [1.05, 2.86] 3.3e-2 195
15 years 0.01 1.02 [0.60, 1.72] 9.4e-1 81
5 years 0.00 2.39 [1.52, 3.75] 1.7e-4 55
1 year 0.00 5.23 [3.09, 8.84] 6.7e-10 23

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: L12_SKINSUBCUTISNAS – Other and unspecified disorders of skin and subcutaneous tissue
GWS hits:

Survival analyses between endpoints

Plot

before Other and unspecified disorders of skin and subcutaneous tissue
after Other and unspecified disorders of skin and subcutaneous tissue

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Drugs most likely to be purchased after Other and unspecified disorders of skin and subcutaneous tissue

Endpoint not on priority list, no data to show.