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Other and unspecified psoriasis

DOID EFO MESH SNOMED PheWeb

L12_PSORI_NAS

psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L40.8, L40.9
Hospital discharge: ICD-9 6968X
Hospital discharge: ICD-8 69619
Cause of death: ICD-10 L40.8, L40.9
Cause of death: ICD-9 6968X
Cause of death: ICD-8 69619

2 out of 7 registries used, show all original rules.

1712

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Check minimum number of events None

1712

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Include endpoints None

1712

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Remove individuals based on genotype QC

1667

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L12_PSORI_NAS

Control definitions

Control exclude L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 1667 810 857
Unadjusted prevalence (%) 0.44 0.38 0.52
Mean age at first event (years) 47.81 45.88 49.64

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.41 [1.41, 4.12] 1.3e-3 248
15 years 0.01 1.53 [1.02, 2.29] 4.1e-2 113
5 years 0.00 2.84 [1.95, 4.14] 5.7e-8 66
1 year 0.00 4.06 [2.37, 6.95] 3.3e-7 18

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: L12_PSORI_NAS – Other and unspecified psoriasis
GWS hits: 4

Survival analyses between endpoints

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Plot

before Other and unspecified psoriasis
after Other and unspecified psoriasis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other and unspecified psoriasis

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Endpoint not on priority list, no data to show.