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Other and unspecified skin changes due to chronic exposure to nonionizing radiation

DOID EFO MESH SNOMED PheWeb

L12_NONIONRADISKINNAS

phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L57.8, L57.9
Hospital discharge: ICD-9 7093C
Cause of death: ICD-10 L57.8, L57.9
Cause of death: ICD-9 7093C

2 out of 7 registries used, show all original rules.

366

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Check minimum number of events None

366

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Include endpoints None

366

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Remove individuals based on genotype QC

353

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L12_NONIONRADISKINNAS

Control definitions

Control exclude L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 353 180 173
Unadjusted prevalence (%) 0.09 0.09 0.10
Mean age at first event (years) 66.03 63.44 68.72

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.08 [0.50, 2.31] 8.5e-1 59
15 years 0.00 0.62 [0.27, 1.39] 2.4e-1 31
5 years 0.00 1.04 [0.47, 2.30] 9.3e-1 17
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: L12_NONIONRADISKINNAS – Other and unspecified skin changes due to chronic exposure to nonionizing radiation
GWS hits: 1

Survival analyses between endpoints

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Plot

before Other and unspecified skin changes due to chronic exposure to nonionizing radiation
after Other and unspecified skin changes due to chronic exposure to nonionizing radiation

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other and unspecified skin changes due to chronic exposure to nonionizing radiation

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Endpoint not on priority list, no data to show.