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Hypertrophic scar

DOID EFO MESH PheWeb

L12_HYPETROPHICSCAR

osteoarthritis: A noninflammatory degenerative joint disease occurring chiefly in older persons, characterised by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L91.0
Hospital discharge: ICD-9 7014B
Hospital discharge: ICD-8 70130
Cause of death: ICD-10 L91.0
Cause of death: ICD-9 7014B
Cause of death: ICD-8 70130

2 out of 7 registries used, show all original rules.

1552

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Check minimum number of events None

1552

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Include endpoints None

1552

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Remove individuals based on genotype QC

1476

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L12_HYPETROPHICSCAR

Control definitions

Control exclude L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L91
Name in latin Cicatrix cheloides

Summary Statistics

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Key figures

All Female Male
Number of individuals 1476 1065 411
Unadjusted prevalence (%) 0.39 0.51 0.25
Mean age at first event (years) 40.41 38.87 44.41

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.80 [1.02, 3.20] 4.4e-2 62
15 years 0.01 1.10 [0.59, 2.05] 7.7e-1 27
5 years 0.00 2.19 [1.17, 4.11] 1.4e-2 14
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: L12_HYPETROPHICSCAR – Hypertrophic scar
GWS hits: 5

Survival analyses between endpoints

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Plot

before Hypertrophic scar
after Hypertrophic scar

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hypertrophic scar

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