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Dermatitis herpetiformis

DOID EFO MESH SNOMED PheWeb

L12_DERMATHERP

dermatitis herpetiformis: Dermatitis herpetiformis (DH) is a chronic autoimmune subepidermal bullous disease characterized by grouped pruritic lesions such as papules, urticarial plaques, erythema, and herpetiform vesiculae, with a predominantly symmetrical distribution on extensor surfaces of the elbows (90%), knees (30%), shoulders, buttocks, sacral region, and face of children and adults. Erosions, excoriations and hyperpigmentation usually follow. DH may also appear as a consequence of gluten intolerance.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L13.0
Hospital discharge: ICD-9 6940A|6942
Hospital discharge: ICD-8 693
Cause of death: ICD-10 L13.0
Cause of death: ICD-9 6940A|6942
Cause of death: ICD-8 693

2 out of 7 registries used, show all original rules.

494

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Check minimum number of events None

494

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Include endpoints None

494

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Remove individuals based on genotype QC

483

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L12_DERMATHERP

Control definitions

Control exclude L12_BULLOUS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L13
Name in latin Dermatitis herpetiformis

Summary Statistics

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Key figures

All Female Male
Number of individuals 483 266 217
Unadjusted prevalence (%) 0.13 0.13 0.13
Mean age at first event (years) 44.86 42.82 47.36

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.60 [0.79, 3.26] 1.9e-1 43
15 years 0.01 1.26 [0.69, 2.31] 4.5e-1 21
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: L12_DERMATHERP – Dermatitis herpetiformis
GWS hits:

Survival analyses between endpoints

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Plot

before Dermatitis herpetiformis
after Dermatitis herpetiformis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Dermatitis herpetiformis

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Endpoint not on priority list, no data to show.