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Atopic dermatitis

DOID EFO MESH PheWeb

L12_ATOPIC

atopic eczema: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L20
Hospital discharge: ICD-9 6918
Hospital discharge: ICD-8 691
Hospital discharge: excluded ICD-9 6918X
Cause of death: ICD-10 L20
Cause of death: ICD-9 6918
Cause of death: ICD-8 691
Cause of death: excluded ICD-9 6918X
KELA reimbursements: KELA codes ANY
KELA reimbursements: ICD-10 L20

3 out of 7 registries used, show all original rules.

13910

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Check minimum number of events None

13910

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Include endpoints None

13910

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Remove individuals based on genotype QC

13473

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L12_ATOPIC

Control definitions

Control exclude L12_DERMATITISECZEMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L20-L30
Name in latin Dermatitis atopica

Summary Statistics

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Key figures

All Female Male
Number of individuals 13473 9603 3870
Unadjusted prevalence (%) 3.57 4.56 2.33
Mean age at first event (years) 29.98 30.18 29.47

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.96 [1.46, 2.64] 8.4e-6 348
15 years 0.01 1.23 [0.88, 1.71] 2.2e-1 146
5 years 0.00 2.44 [1.74, 3.44] 3.0e-7 78
1 year 0.00 4.88 [3.12, 7.63] 3.4e-12 28

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: L12_ATOPIC – Atopic dermatitis
GWS hits: 48

Survival analyses between endpoints

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Plot

before Atopic dermatitis
after Atopic dermatitis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Atopic dermatitis

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