Actinic keratosis


actinic keratosis: A precancerous lesion of the skin composed of atypical keratinocytes. It is characterized by the presence of thick, scaly patches of skin. Several histologic variants have been described, including atrophic, acantholytic, and hyperkeratotic variants.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 L57.0
Hospital discharge: ICD-9 7020A
Hospital discharge: ICD-8 70200
Cause of death: ICD-10 L57.0
Cause of death: ICD-9 7020A
Cause of death: ICD-8 70200

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints None


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Remove individuals based on genotype QC


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Control definitions


Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L57
Name in latin Keratosis actinica

Summary Statistics

Key figures

All Female Male
Number of individuals 11081 5601 5480
Unadjusted prevalence (%) 2.94 2.66 3.30
Mean age at first event (years) 71.98 70.92 73.06


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.92 [1.57, 2.34] 1.6e-10 1207
15 years 0.01 1.01 [0.84, 1.22] 9.0e-1 548
5 years 0.00 1.93 [1.64, 2.27] 4.4e-15 488
1 year 0.00 2.08 [1.65, 2.63] 7.9e-10 110

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: L12_ACTINKERA – Actinic keratosis
GWS hits: 32

Survival analyses between endpoints


before Actinic keratosis
after Actinic keratosis

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Drugs most likely to be purchased after Actinic keratosis

Endpoint not on priority list, no data to show.