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Ulcerative colitis (strict definition, require KELA, min 2 HDR)

DOID EFO MESH SNOMED PheWeb

K11_UC_STRICT2

ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions

K11_KELAUC
and K11_ULCERnumber of events
>1

5714

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K51
Hospital discharge: ICD-9 556
Hospital discharge: ICD-8 5631|569
Hospital discharge: excluded ICD-9 5564A
Cause of death: ICD-10 K51
Cause of death: ICD-9 556
Cause of death: ICD-8 5631|569
Cause of death: excluded ICD-9 5564A

2 out of 7 registries used, show all original rules.

5183

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Check minimum number of events None

5183

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Include endpoints None

5183

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Remove individuals based on genotype QC

5034

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K11_UC_STRICT2

Control definitions

Control conditions not K11_KELAUC

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3
Parent code in ICD-10 K50-K52
Name in latin Colitis ulcerosa

Summary Statistics

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Key figures

All Female Male
Number of individuals 5034 2567 2467
Unadjusted prevalence (%) 1.33 1.22 1.48
Mean age at first event (years) 40.20 37.47 43.04

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.59 [1.09, 2.32] 1.5e-2 259
15 years 0.01 1.06 [0.74, 1.52] 7.6e-1 110
5 years 0.00 1.97 [1.38, 2.83] 2.2e-4 52
1 year 0.00 2.97 [1.69, 5.22] 1.6e-4 14

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_UC_STRICT2 – Ulcerative colitis (strict definition, require KELA, min 2 HDR)
GWS hits: 32

Survival analyses between endpoints

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Plot

before Ulcerative colitis (strict definition, require KELA, min 2 HDR)
after Ulcerative colitis (strict definition, require KELA, min 2 HDR)

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Drugs most likely to be purchased after Ulcerative colitis (strict definition, require KELA, min 2 HDR)

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