≡ Risteys
R9

Documentation Changelog GitHub Contact & Feedback

Diaphragmatic hernia

DOID EFO MESH PheWeb

K11_DIAHER

congenital diaphragmatic hernia: Congenital diaphragmatic hernia (CDH) is a posterolateral defect of the diaphragm that allows passage of abdominal viscera into the thorax, leading to respiratory insufficiency and persistent pulmonary hypertension with high mortality.

Endpoint definition

↥
FinnGen phenotype data

392423 individuals

diagram downward connector

Apply sex-specific rule None

392423

diagram downward connector

Check conditions None

392423

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K44
Hospital discharge: ICD-9 5513|5523|5533
Hospital discharge: ICD-8 5513
Cause of death: ICD-10 K44
Cause of death: ICD-9 5513|5523|5533
Cause of death: ICD-8 5513

2 out of 7 registries used, show all original rules.

12180

diagram downward connector

Check minimum number of events None

12180

diagram downward connector

Include endpoints None

12180

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

11757

diagram downward connector
K11_DIAHER

Control definitions

Control exclude K11_HERNIA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K40-K46
Name in latin Hernia diaphragmatica

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 11757 6973 4784
Unadjusted prevalence (%) 3.12 3.31 2.88
Mean age at first event (years) 60.47 60.04 61.11

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.14 [1.68, 2.74] 1.1e-9 1284
15 years 0.01 1.29 [1.07, 1.57] 9.1e-3 550
5 years 0.00 2.84 [2.41, 3.35] 3.1e-35 423
1 year 0.00 5.71 [4.65, 7.01] 4.5e-62 166

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: K11_DIAHER – Diaphragmatic hernia
GWS hits: 9

Survival analyses between endpoints

↥

Plot

before Diaphragmatic hernia
after Diaphragmatic hernia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diaphragmatic hernia

↥