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Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified

DOID EFO MESH SNOMED PheWeb

J10_VOCALLARYNX

laryngeal disease: A non-neoplastic or neoplastic disorder that affects the larynx. Representative examples include laryngitis, vocal cord polyp, squamous papilloma, and carcinoma. [database_cross_reference: NCIT:P378]

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 J34, J38, J39
Hospital discharge: ICD-9 478
Hospital discharge: ICD-8 508
Hospital discharge: excluded ICD-8 50803
Cause of death: ICD-10 J34, J38, J39
Cause of death: ICD-9 478
Cause of death: ICD-8 508
Cause of death: excluded ICD-8 50803

2 out of 7 registries used, show all original rules.

20279

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Check minimum number of events None

20279

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Include endpoints None

20279

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Remove individuals based on genotype QC

19530

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J10_VOCALLARYNX

Control definitions

Control exclude J10_UPPERDIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Similar endpoints

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Summary Statistics

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Key figures

All Female Male
Number of individuals 19530 9837 9693
Unadjusted prevalence (%) 5.18 4.67 5.83
Mean age at first event (years) 48.18 46.66 49.73

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.71 [1.23, 2.37] 1.3e-3 1315
15 years 0.01 1.14 [0.88, 1.48] 3.2e-1 547
5 years 0.00 2.29 [1.86, 2.82] 4.2e-15 302
1 year 0.00 6.79 [5.42, 8.51] 5.3e-62 170

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: J10_VOCALLARYNX – Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified
GWS hits: 1

Survival analyses between endpoints

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Plot

before Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified
after Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified

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Drugs most likely to be purchased after Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified

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Endpoint not on priority list, no data to show.