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Thromboangiitis obliterans

DOID EFO MESH SNOMED PheWeb

I9_THROMBANG

thromboangiitis obliterans: Buerger disease, also known as thromboangiitis obliterans (TAO), is a rare inflammatory non-necrotizing vascular disease affecting the small- and medium-sized arteries and veins of the upper and lower extremities characterized by endarteritis and vaso-occlusion due to occlusive thrombus development. The development and progression of the disease is consistently associated with exposure to tobacco.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I73.1
Hospital discharge: ICD-9 4431A
Hospital discharge: ICD-8 44310
Cause of death: ICD-10 I73.1
Cause of death: ICD-9 4431A
Cause of death: ICD-8 44310

2 out of 7 registries used, show all original rules.

111

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Check minimum number of events None

111

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Include endpoints None

111

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Remove individuals based on genotype QC

108

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I9_THROMBANG

Control definitions

Control exclude I9_DOAAC

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I73
Name in latin Tromboangi(i)tis obliterans (Bürger)

Summary Statistics

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Key figures

All Female Male
Number of individuals 108 36 72
Unadjusted prevalence (%) 0.03 0.02 0.04
Mean age at first event (years) 50.58 46.43 52.65

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_THROMBANG – Thromboangiitis obliterans
GWS hits:

Survival analyses between endpoints

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Plot

before Thromboangiitis obliterans
after Thromboangiitis obliterans

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Drugs most likely to be purchased after Thromboangiitis obliterans

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Endpoint not on priority list, no data to show.