Nonischemic cardiomyopathy

I9_NONISCHCARDMYOP_STRICT

dilated cardiomyopathy: Cardiomyopathy which is characterized by dilation and contractile dysfunction of the left and right ventricles. It may be idiopathic, or it may result from a myocardial infarction, myocardial infection, or alcohol abuse. It is a cause of congestive heart failure.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions

not I9_IHD
and not I9_HYPERTROCARDMYOP

326069

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I42.0, I51.1
Hospital discharge: ICD-9 4281
Cause of death: ICD-10 I42.0, I51.1
Cause of death: ICD-9 4281

2 out of 7 registries used, show all original rules.

1681

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Check minimum number of events None

1681

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Include endpoints None

1681

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Remove individuals based on genotype QC

1639

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I9_NONISCHCARDMYOP_STRICT

Control definitions

Control conditions not I9_IHD
and not I9_HYPERTROCARDMYOP

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 1639 479 1160
Unadjusted prevalence (%) 0.43 0.23 0.70
Mean age at first event (years) 57.55 56.51 57.98

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.25 [2.56, 7.05] 2.3e-8 243
15 years 0.01 2.43 [1.64, 3.60] 9.4e-6 101
5 years 0.00 3.93 [2.67, 5.77] 3.2e-12 64
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_NONISCHCARDMYOP_STRICT – Nonischemic cardiomyopathy
GWS hits: 5

Survival analyses between endpoints

Plot

before Nonischemic cardiomyopathy
after Nonischemic cardiomyopathy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Nonischemic cardiomyopathy

Endpoint not on priority list, no data to show.