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Coronary atherosclerosis

DOID EFO MESH SNOMED PheWeb

I9_CORATHER

heart aneurysm: A localized bulging or dilatation in the muscle wall of a heart (myocardium), usually in the left ventricle. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are hematoma caused by myocardial rupture.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I24, I25, T82.2, Z95.1
Hospital discharge: ICD-9 414|9960A
Hospital discharge: ICD-8 414
Hospital discharge: excluded ICD-10 I25.3
Cause of death: ICD-10 I24, I25, T82.2, Z95.1
Cause of death: ICD-9 414|9960A
Cause of death: ICD-8 414
Cause of death: excluded ICD-10 I25.3

2 out of 7 registries used, show all original rules.

49049

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Check minimum number of events None

49049

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Include endpoints None

49049

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Remove individuals based on genotype QC

47550

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I9_CORATHER

Control definitions

Control exclude I9_ISCHHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 47550 14362 33188
Unadjusted prevalence (%) 12.61 6.81 19.96
Mean age at first event (years) 67.54 68.44 67.14

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.19 [3.82, 4.61] <1e-100 15678
15 years 0.01 2.28 [2.09, 2.49] 5.5e-73 5488
5 years 0.00 3.90 [3.63, 4.20] <1e-100 3646
1 year 0.01 25.67 [23.35, 28.21] <1e-100 5331

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_CORATHER – Coronary atherosclerosis
GWS hits: 88

Survival analyses between endpoints

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Plot

before Coronary atherosclerosis
after Coronary atherosclerosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Coronary atherosclerosis

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